What kind of cell is mitochondria found in
Mitochondria are membrane-bound organelles, but they're membrane-bound with two different membranes. And that's quite unusual for an intercellular organelle.
Those membranes function in the purpose of mitochondria, which is essentially to produce energy. That energy is produced by having chemicals within the cell go through pathways, in other words, be converted. The theory of endosymbiosis suggests that mitochondria were once free living organisms on their own that used aerobic respiration. Larger anaerobic cells simply engulfed these aerobic mitochondria to use their energy, giving rise to complex cells we find today such as those in our bodies.
Timeline of Mitochondrial Disease The area of mitochondrial medicine is extremely new, and therefore ever expanding. The discovery of most mitochondrial diseases actually only occurred within the last 30 years. The timeline below shows some important milestones in the history of mitochondrial medicine:.
How is energy made? Our food contains the building blocks of life known as macromolecules, namely carbohydrates, proteins and fats. The energy stored in the molecular bonds of these molecules is converted into a usable energy source in the body known as ATP. ATP is the only energy currency that can be used in our bodies. This concept is analogous to energy from power plants entering our homes. Similar to macromolecules, there are many sources of energy including hydro, wind, nuclear etc.
Similarly, the inner membrane, which is highly convoluted so that a large number of infoldings called cristae are formed, also allows only certain molecules to pass through it and is much more selective than the outer membrane.
To make certain that only those materials essential to the matrix are allowed into it, the inner membrane utilizes a group of transport proteins that will only transport the correct molecules. Together, the various compartments of a mitochondrion are able to work in harmony to generate ATP in a complex multi-step process.
Mitochondria are generally oblong organelles, which range in size between 1 and 10 micrometers in length, and occur in numbers that directly correlate with the cell's level of metabolic activity. The organelles are quite flexible, however, and time-lapse studies of living cells have demonstrated that mitochondria change shape rapidly and move about in the cell almost constantly. Movements of the organelles appear to be linked in some way to the microtubules present in the cell, and are probably transported along the network with motor proteins.
Consequently, mitochondria may be organized into lengthy traveling chains, packed tightly into relatively stable groups, or appear in many other formations based upon the particular needs of the cell and the characteristics of its microtubular network.
Presented in Figure 2 is a digital image of the mitochondrial network found in the ovarian tissue from a mountain goat relative, known as the Himalayan Tahr, as seen through a fluorescence optical microscope. The extensive intertwined network is labeled with a synthetic dye named MitoTracker Red red fluorescence that localizes in the respiring mitochondria of living cells in culture.
The rare twin nuclei in this cell were counterstained with a blue dye cyan fluorescence to denote their centralized location in relation to the mitochondrial network. Fluorescence microscopy is an important tool that scientists use to examine the structure and function of internal cellular organelles. The mitochondrion is different from most other organelles because it has its own circular DNA similar to the DNA of prokaryotes and reproduces independently of the cell in which it is found; an apparent case of endosymbiosis.
Scientists hypothesize that millions of years ago small, free-living prokaryotes were engulfed, but not consumed, by larger prokaryotes, perhaps because they were able to resist the digestive enzymes of the host organism. The two organisms developed a symbiotic relationship over time, the larger organism providing the smaller with ample nutrients and the smaller organism providing ATP molecules to the larger one.
Eventually, according to this view, the larger organism developed into the eukaryotic cell and the smaller organism into the mitochondrion. Mitochondrial DNA is localized to the matrix, which also contains a host of enzymes, as well as ribosomes for protein synthesis. They have no nucleus; instead their genetic material is free-floating within the cell.
They also lack the many membrane-bound organelles found in eukaryotic cells. Thus, prokaryotes have no mitochondria. In a review of the history of mitochondria in the Journal of Cell Biology, authors Lars Ernster and Gottfried Schatz note that the first true observation of mitochondria was by Richard Altmann in As described by Karen Hales, a professor of biology at Davidson College, in Nature Education , these organelles are dynamic, and constantly fuse together to form chains, and then break apart.
Individual mitochondria are capsule shaped, with an outer membrane and an undulating inner membrane, which resembles protruding fingers. These membranous pleats are called cristae, and serve to increase the overall surface area of the membrane. When compared to cristae, the outer membrane is more porous and is less selective about which materials it lets in. The matrix is the central portion of the organelle and is surrounded by cristae. It contains enzymes and DNA. Mitochondria are unlike most organelles with an exception of plant chloroplasts in that they have their own set of DNA and genes that encode proteins.
While plant and animal mitochondria do not differ in their basic structure, Dan Sloan , an assistant professor at the University of Colorado said, their genomes are quite different. They vary in size and structure. According to Sloan, the genomes of most flowering plants are about , base pairs in size, and can be as large as 10 million base pairs.
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